The prostacyclin analog beraprost sodium (BPS) ameliorates characteristics of metabolic syndrome in obese Zucker (fatty) rats. Running title: BPS ameliorates diabetes mellitus

Running title: BPS ameliorates diabetes mellitus Nahoko Sato, Masayuki Kaneko, Mitsutaka Tamura and Hajimu Kurumatani The First Pharmacology Laboratory, Pharmaceutical Research Labs, Toray Industries. Inc., Kamakura, Kanagawa, Japan All correspondence should be addressed to: Nahoko Sato E-mail: [email protected] Submitted 28 September 2009 and accepted 21 December 2009. This is an uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association, publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes in print and online at http://diabetes.diabetesjournals.org. Diabetes Publish Ahead of Print, published online January 12, 2010